Doctors News Hubb
Advertisement Banner
  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us
No Result
View All Result
  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us
No Result
View All Result
Doctors News Hubb
No Result
View All Result
Home News

Low dose aspirin not associated with congenital abnormalities

admin by admin
November 14, 2022
in News


1. Low-dose aspirin is not significantly associated with congenital anomalies even when started in the first trimester.

2. Other factors found to be associated with congenital anomalies include history of previous fetal abnormalities and history of previous spontaneous abortions

Evidence Rating Level: 2 (Good)

Low-dose aspirin (LDA) has been used effectively in the treatment of pre-eclampsia, as well as in patients undergoing recurrent pregnancy loss due to thrombophilia. Previous animal studies have found that high-dose aspirin in the first and second trimester was associated with a variety of congenital anomalies. Human studies have also found a possible association between aspirin and fetal gastroschisis and cryptorchidism, as well as concerns regarding premature closure of ductus arteriosus. This retrospective cohort study sought to further expand upon this literature with collected data from 2736 patients and 2856 fetuses, of which 1684 of these patients took LDA, with an average daily dose of 67.6mg. The patients in the LDA group were older, with a higher primipara rate and more previous spontaneous abortions, as well as were more likely to have chronic hypertension and rheumatic disease. Starting at the 12th week of gestation congenital anomalies were screened for every 4 weeks using ultrasound or MRI, karyotype analysis and postpartum examinations. Neonatal examinations were also conducted at birth. The rate of fetal abnormalities in the LDA group was found to be 3.3% and the rate of fetal abnormalities in the control group was found to be 2.8%, this difference was not significant (P=0.421). Many of these patients also started taking LDA in their first trimester which is a critical time for most congenital anomalies, suggesting that even at the most critical period there is no significant negative impact from the use of LDA. This study did find that previous spontaneous abortions (OR = 1.15, 95% CI: 1.01–1.31, P = 0.040) and a history of fetal malformations (OR = 3.22, 95% CI: 1.12–9.20, P = 0.029) were associated with a risk of fetal congenital abnormalities. This study was done in the Chinese population, thus further studies on the effects of LDA in different ethnic populations are needed to generalize these results. Congenital anomalies are thought to have a multifactorial and complex pathogenesis, with two of the factors found by this study to be a history of fetal abnormalities and a history of spontaneous abortions. This study does show however, that in the Chinese population LDA was not found to be associated with congenital anomalies and is likely safe to use in pregnancy for prophylaxis and treatment of other conditions.

Click to read the study in BMC Pregnancy and Childbirth

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.



Source link

Advertisement Banner
Previous Post

Summit Health’s Jeff Alter plans future post-acquisition by VillageMD

Next Post

Sleep-Related Breathing Disorders – The Sleep Doctor

Related Posts

News

Insights from Normalization Process Theory

March 23, 2023
News

Transdermal Testosterone Pretreatment Improves Live Birth Rates in Poor Responders

March 22, 2023
News

Ph-positive Acute Lymphoblastic Leukaemia Treated with Ponatinib and Blinatumomab

March 21, 2023
News

High-Risk Hodgkin Lymphoma and BV+Nivolumab After HSCT

March 20, 2023
News

History of Adverse Pregnancy Outcomes Linked to Coronary Artery Disease

March 19, 2023
News

American College of Cardiology, March 4 to 6

March 18, 2023
Next Post

Sleep-Related Breathing Disorders - The Sleep Doctor

Recommended

Metformin and Survival in Diabetes-related In-hospital Cardiac Arrest

3 months ago

Centene to sell Magellan Specialty Health to Evolent Health

4 months ago

HHS’ $350M COVID-19 vaccine initiative

4 months ago

988 mental health hotline resumes after national service outage

4 months ago

ER Nurse Follows Protocol, Avoids Negligence Lawsuit

3 months ago

© 2022 Doctors News Hubb All rights reserved.

Use of these names, logos, and brands does not imply endorsement unless specified. By using this site, you agree to the Privacy Policy and Terms & Conditions.

Navigate Site

  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us

Newsletter Sign Up.

No Result
View All Result
  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us

© 2022 Doctors News Hubb All rights reserved.