Doctors News Hubb
Advertisement Banner
  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us
No Result
View All Result
  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us
No Result
View All Result
Doctors News Hubb
No Result
View All Result
Home News

COVID-19 Vaccination During Pregnancy Benefits Neonates and Pregnant Individuals

admin by admin
December 26, 2022
in News


Findings that show COVID-19 vaccination during pregnancy improves neonatal outcomes can serve “a critical role” in counseling these patients about the vaccine.


“While I was rotating in the OB/GYN department as an intern, I saw several cases of pregnant individuals with severe COVID-19 who had to give birth during the second trimester,” Watanabe Atsuyuki, MD, explained. “Although the neonates were negative for SARS-CoV-2, they still experienced complications, including respiratory failure and other conditions along with prematurity. Previous studies have also shown that pregnant individuals with COVID-19 can have newborns at higher risk for NICU admission, stillbirth, preterm birth, and other peripartum events compared with those without COVID-19.”

As a result, “we focused on neonatal outcomes as well as maternal outcomes” for a study published in JAMA Pediatrics, Dr. Atsuyuki noted. Together with Toshiki Kuno, MD, PhD, FESC, FSCAI, Dr. Atsuyuki and the rest of the study team conducted a systematic review and meta-analysis of nine observational studies. Specific neonatal parameters, including preterm birth, small for gestational age, low Apgar score, NICU admission, and intrauterine fetal death (IFD), served as the primary outcomes, while maternal outcomes served as the secondary outcomes, including SARS-CoV-2 infection, Cesarean delivery, postpartum hemorrhage, and chorioamnionitis.

Vaccination Reduces Risk for Maternal & Neonatal Events

The analysis included 81,349 vaccinated (mean age, 32-35) and 255,346 unvaccinated individuals (mean age, 29.5-33) during pregnancy. Almost all vaccinated individuals (98.2%) received mRNA vaccines.

Six studies described the number of COVID-19 vaccine doses; 52,295 of 61,255 individuals (85.4%) received two doses of mRNA vaccines during pregnancy. Seven studies documented the timing of the first vaccine among 58,548 individuals. Nearly half of all individuals in these studies (N=27,988; 47.8%) received the first vaccine during the third trimester. Slightly fewer received the first injection during the second trimester (N=27,108; 46.3%). The smallest proportion of patients (N=3,452; 5.9%) received the first dose during the first trimester.

“COVID-19 vaccination during pregnancy was associated with lower risks for NICU admission and IFD (Infographic),” Dr. Kuno noted. “This is probably because vaccinated mothers have a lower risk for SARS-CoV-2 infection, and maternal SARS-CoV-2 infection may be a risk factor for worse neonatal outcomes. In addition, COVID-19 vaccination during pregnancy was not associated with higher risks for maternal and neonatal events, such as Cesarean delivery, postpartum hemorrhage, chorioamnionitis, preterm birth, small size for gestational age, and lower Apgar scores.”

Specifically, COVID-19 vaccination in pregnancy was associated with reduced risk for NICU admission (OR, 0.88; 95% CI, 0.80-0.97) and IFD (OR, 0.73; 95% CI, 0.57-0.94). Vaccination was also associated with a decreased risk for maternal SARS-CoV-2 infection (OR, 0.46; 95% CI, 0.22-0.93).

Findings Establish Benefits of Vaccination for Newborns

Drs. Atsuyuki, Kuno, and colleagues noted the role of the findings in establishing the safety for newborns of COVID-19 vaccination during pregnancy, which could serve “a critical role” in counseling pregnant patients about the teratogenicity of the COVID-19 vaccine.

“COVID-19 vaccination during pregnancy may be associated with better neonatal outcomes without causing noticeable adverse effects,” Dr. Kuno said. “COVID-19 vaccination during pregnancy may not only provide maternal protection against SARS-CoV-2 but may also be associated with better neonatal outcomes. Providers should consider these risk-benefit balances when counseling patients.”

The study results also described maternal protection against SARS-CoV-2 “paramount,” given that most pregnant patients with COVID-19 who required intensive care were not vaccinated.

“Given the promising efficacy of COVID-19 vaccination in preventing maternal SARS-CoV-2 infection and the critical association between COVID-19 and neonatal/maternal outcomes, our findings further underlined the importance of maternal protection against SARS-CoV-2 infection,” the researchers wrote.



Source link

Advertisement Banner
Previous Post

House passes $1.7T spending bill

Next Post

Senate passes omnibus bill to fund government

Related Posts

News

Unvaccinated status increases risk of long COVID symptoms

January 29, 2023
News

Rezafungin is non-inferior to caspofungin in the treatment of candidemia and invasive candidiasis

January 28, 2023
News

An Analysis of HDL-bound Apolipoproteins in NAFLD Patients with Advanced Liver Fibrosis

January 27, 2023
News

Restrictive, Liberal Fluid Strategies Yield Similar Outcomes for Sepsis-Induced Hypotension

January 26, 2023
News

Mild to Moderate Cerebral Palsy in Young Children Treated with Vibration Therapy

January 25, 2023
News

Serrated Neoplasia Pathway to Colorectal Cancer Reveals Early Immune and Molecular Alterations

January 24, 2023
Next Post

Senate passes omnibus bill to fund government

Recommended

HHS Medicaid rule clarifies nonclinical care reimbursement

3 weeks ago

Rezafungin is non-inferior to caspofungin in the treatment of candidemia and invasive candidiasis

1 day ago

Creating the Most Advanced Hand Hygiene Technology

1 week ago

How to Pass the NCLEX with 75 Questions in One Attempt

3 months ago

Science writer addresses COVID-19 virus origin story in new book

3 weeks ago

© 2022 Doctors News Hubb All rights reserved.

Use of these names, logos, and brands does not imply endorsement unless specified. By using this site, you agree to the Privacy Policy and Terms & Conditions.

Navigate Site

  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us

Newsletter Sign Up.

No Result
View All Result
  • Home
  • News
  • Healthcare
  • Public Health
  • Paramedic
  • Nursing
  • Contact Us

© 2022 Doctors News Hubb All rights reserved.